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Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular types with recombination purpose.

Multicolor imaging on the bacterial nucleoid and cell division proteins with blue, orange, and near-infrared fluorescent proteins

Because 2000, Dekker has shifted the leading focus of his perform towards biophysics in which he scientific tests the properties of single biomolecules and cells using the instruments of nanotechnology. This alteration of area was driven by his fascination to the extraordinary functioning of biological molecular structures, and also because of the long-term viewpoint that lots of appealing discoveries may be anticipated On this discipline.[five] Latest strains of investigate in his biophysics team are during the parts of:[six]

That could be a dream of mine and we set to operate which has a mouth watering dose of naivety. This can be a thing that will probably yield breathtaking ends in the for a longer period term, but that does not issue. You should not only want to operate within the concerns of tomorrow, but in addition to the questions in the working day just after tomorrow.’

Our investigation ranges through the biophysics of DNA to synthetic cells and over and above. Remember to have a look beneath in the spectrum https://www.ceesdekker.net of our present tasks.

We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks and this evaluate the elemental purpose of spatial confinement for the molecular and mobile stage. Our projects involve the following:

Dynamic ParB–DNA interactions initiate and manage a partition condensate for bacterial chromosome segregation

Imagine if, as an alternative to utilizing common prime-down silicon electronics, transistors might be designed from the bottom up applying single natural and organic molecules as being the switching components? This concept, which became The idea of today’s subject of molecular electronics, first emerged from the 1970s.

Resolving the phase dimension in condensin-pushed DNA loop extrusion identifies ATP binding as being the phase-generating process

Case in point (4) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim with the pore is highlighted in crimson, and a 3D rendering with the motion with the DNA rod is displayed.

2001, discovery of one-electron transistors at room temperature dependant on nanotubes; realization of initially logic circuits with carbon nanotube gadgets; and discovery of the molecular framework of DNA fix enzymes with AFM

Developments in nanotechnology from the nineties designed constructing electronic units from solitary molecules a chance. Cees Dekker recounts how his team made a home-temperature transistor dependant on only one carbon nanotube.

2004, discovery of latest physics in translocation of DNA via nanopores; first experimental review of ions conduction in nanofluidic channels; very first electrochemistry with person one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; first electrical docking of microtubules on kinesin-coated nanostructures; initially biophysics characterization in the mechanical properties of double-stranded RNA; and initially single-molecule analyze of DNA translocation by a restriction-modification enzyme.